The Hidden Gene Behind Depression, Fatigue, and Brain Fog | Dr. Colbert on MTHFR Ep. 1

🧬 Could a Hidden Gene Be Causing Your Fatigue, Brain Fog, or Depression?

If you’re struggling with chronic fatigue, low mood, anxiety, or brain fog, the real culprit may be genetic — and surprisingly common. In this eye-opening episode, Dr. Don Colbert, MD is joined by his son Kyle, wife Mary, and daughter-in-law Meredith to explore a powerful but often overlooked factor in your health: the MTHFR gene mutation.

This mutation affects nearly 50% of Americans and plays a critical role in how your body creates energy, supports brain function, regulates mood, and detoxifies. Yet most people have never been tested for it — and continue to suffer silently from symptoms that could be addressed naturally.

🔍 What You’ll Learn in This Episode:

✔️ What the MTHFR gene does and why it’s essential for mental clarity, mood, cardiovascular health, and hormone balance
✔️ How homocysteine, a toxic amino acid, builds up in the body due to MTHFR dysfunction — and how it’s linked to heart disease, Alzheimer’s, osteoporosis, and even cancer
✔️ The difference between minor (heterozygous) and major (homozygous) mutations — and what each means for your health
✔️ Dr. Colbert’s personal story, testing protocol, and natural support regimen for MTHFR-related symptoms like depression, brain fog, fatigue, and miscarriage
✔️ How Christian counselors and therapists can better understand and support clients with trauma and chronic mood disorders linked to methylation issues

This conversation is an incredible resource for anyone looking to take control of their health through functional medicine, genetics, and faith-based healing.

🧪 Tests to Know

✅ MTHFR Gene Test

Easily accessible through a doctor or at-home kit.
• Order from SelfDecode
• 23andMe DNA Testing

To analyze results:
• Upload to Genetic Genie for a free MTHFR interpretation

✅ Homocysteine Blood Test

• Ask your doctor or local lab
• Optimal range: below 10 µmol/L
Elevated homocysteine is a warning sign for those with MTHFR mutations — and can often be reversed naturally.

🧠 Dr. Colbert’s Solution: Brain Zone Basic

To address the root cause, Dr. Colbert recommends Brain Zone Basic — his signature formula for supporting methylation, neurotransmitter production, and cognitive function.

Key Ingredients:

• 5mg Methylated Folate (5-MTHF) – bypasses genetic defects in folate metabolism
• NAD & B12 (methylcobalamin) – boost cellular energy and brain clarity
• Trimethylglycine – Supports healthy homocysteine levels
• Curcumin – supports detox and free radical balance in the brain

👉 Recommended Dosage: 2 capsules twice daily or as directed by your healthcare provider

📚 Also Recommended:
The Brain Zone Book by Dr. Don Colbert
Learn how to protect your brain from aging, Alzheimer’s, and neuroinflammation using nutritional and lifestyle strategies grounded in science and scripture.

🙏 Final Thoughts

At Divine Health and DrColbert.com, we believe knowledge is power — especially when it comes to the intersection of genetics, nutrition, and faith. Whether you’re a patient, counselor, or caregiver, understanding your body’s methylation pathway could be the key to lasting energy, joy, and clarity.